Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD)
1999
Study on Vascular Damage from Photodynamic Therapy
publication
Author Information
Author(s): Fingar V H, Kik P K, Haydon P S, Cerrito P B, Tseng M, Abang E, Wieman T J
Primary Institution: University of Louisville
Hypothesis
Does the timing of light treatment after BPD injection affect vascular damage and tumor regression?
Conclusion
The timing of light treatment after BPD injection significantly influences vascular damage and tumor regression.
Supporting Evidence
- Blood flow stasis was limited to tumor microvasculature when light treatment was given shortly after BPD injection.
- No acute changes were observed in vessels when light was given 180 min after BPD injection.
- Tumor regression occurred in all animals given PDT with BPD.
Takeaway
This study found that giving light treatment shortly after a drug injection can help target tumors better and cause more damage to them.
Methodology
Rats with chondrosarcoma were treated with BPD and then given light treatment at various times, with vascular response monitored using microscopy.
Participant Demographics
Rats with chondrosarcoma
Digital Object Identifier (DOI)
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