Comparing Mesna and Forced Diuresis for Preventing Cystitis in Bone Marrow Transplant Patients
Author Information
Author(s): J.M. Hows, A. Mehta, L. Ward, K. Woods, R. Perez, M.Y. Gordon, E.C. Gordon-Smith
Primary Institution: Royal Postgraduate Medical School, London
Hypothesis
Is mesna more effective than forced diuresis in preventing cyclophosphamide-induced haemorrhagic cystitis in marrow transplant recipients?
Conclusion
Mesna is more effective than forced diuresis in preventing cyclophosphamide-induced haemorrhagic cystitis in BMT recipients.
Supporting Evidence
- Nine out of 26 patients receiving forced diuresis developed macroscopic haematuria, while only four out of 32 mesna patients did.
- Mesna treatment resulted in a significantly lower incidence of macroscopic haematuria compared to forced diuresis.
- Patients treated with mesna required less nursing time than those undergoing forced diuresis.
Takeaway
This study found that a medicine called mesna helps prevent a painful bladder condition in patients getting a special type of cancer treatment, and it works better than drinking a lot of fluids.
Methodology
A prospective randomised study comparing mesna and forced diuresis in 61 bone marrow transplant patients.
Limitations
The study did not explore all potential causes of haemorrhagic cystitis and had a small sample size.
Participant Demographics
Patients included 34 receiving mesna and 27 receiving forced diuresis, with a mix of leukaemic and aplastic patients.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
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