VEGF as a Prognostic Factor in Soft Tissue Sarcomas
Author Information
Author(s): Yudoh K, Kanamori M, Ohmori K, Yasuda T, Aoki M, Kimura T
Primary Institution: Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Hypothesis
The study investigates the clinical relevance of neovascularity assessed by microvessel density and the concentration of vascular endothelial growth factor in the tumour tissue of patients with soft tissue sarcoma.
Conclusion
The concentration of VEGF in the tumour tissue is an independent prognostic factor for disease outcome in patients with soft tissue sarcoma.
Supporting Evidence
- Higher VEGF concentration in tumor tissue is correlated with poor overall survival.
- Patients with higher VEGF levels had a greater probability of local recurrence and metastasis.
- VEGF concentration is an independent prognostic factor regardless of histologic type.
Takeaway
This study found that higher levels of a substance called VEGF in tumor tissue can mean a worse outcome for patients with soft tissue sarcomas.
Methodology
MVD was measured by counting vessels stained with factor VIII antibody, and VEGF concentration was determined by enzyme-linked immunosorbent assay.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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