Impact of Esophageal Carcinoma Histology on Surgery Outcomes
Author Information
Author(s): Charles E. Woodall, Ryan Duvall, Charles R. Scoggins, Kelly M. McMasters, Robert C. G. Martin
Primary Institution: University of Louisville School of Medicine
Hypothesis
Tumor histology is a powerful surrogate marker for perioperative morbidity in esophageal cancer surgery.
Conclusion
Squamous cell carcinoma (SCC) is the best predictor of prolonged ICU stay and more severe complications following esophagectomy.
Supporting Evidence
- SCC patients had a higher incidence of prior pulmonary disease than AC patients (23.8% vs. 5.8%).
- SCC patients were more likely to have a prolonged ICU stay than AC patients (P = .004).
- SCC group experienced higher grades of complications (P = .0053).
- Overall, 70% of patients experienced some sort of complication.
Takeaway
This study found that patients with squamous cell carcinoma tend to have more complications and longer hospital stays after surgery compared to those with adenocarcinoma.
Methodology
The study reviewed records of 73 patients who underwent esophagogastrectomy, analyzing demographics, complications, and outcomes based on tumor histology.
Limitations
The small sample size of SCC patients limits the impact of the data.
Participant Demographics
Median age was 61, with 75.3% male and 74% Caucasian.
Statistical Information
P-Value
P = .004 for higher incidence of prior pulmonary disease in SCC group.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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