Serotonergic Contribution to Boys' Behavioral Regulation
2011

Serotonin and Boys' Behavior Regulation

Sample size: 23 publication 10 minutes Evidence: moderate

Author Information

Author(s): Nantel-Vivier Amélie, Pihl Robert O., Young Simon N., Parent Sophie, Bélanger Stacey Ageranioti, Sutton Rachel, Dubois Marie-Eve, Tremblay Richard E., Séguin Jean R.

Primary Institution: McGill University

Hypothesis

Boys in the tryptophan group would be dominant but non-aggressive when responding to provocation by a fictitious opponent.

Conclusion

The study provides initial evidence for the feasibility of acute tryptophan supplementation in children and some effect on their behaviors.

Supporting Evidence

  • Boys in the tryptophan group adjusted their level of responding optimally as a function of the level of provocation.
  • Boys in the control group significantly decreased their level of responding towards the end of the competition.
  • Boys in the tryptophan group tended to show greater perspective taking.
  • Boys in the tryptophan group tended to better distinguish facial expressions of fear and happiness.
  • Boys in the tryptophan group tended to provide greater instrumental help to the experimenter.

Takeaway

The study looked at how a special drink with tryptophan might help boys who have trouble controlling their behavior. It found that the drink could help them act better in some situations.

Methodology

The study used a double-blind, acute tryptophan supplementation procedure with boys who had a history of behavior regulation difficulties.

Potential Biases

Potential bias due to small sample size and reliance on parental consent.

Limitations

The small sample size limits the power to detect statistically significant differences.

Participant Demographics

Participants were 23 boys aged 10 years with a history of elevated physical aggression.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0020304

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