The Dual Role of CD95 in T Cell Signaling
Author Information
Author(s): Paulsen Maren, Janssen Ottmar
Primary Institution: Christian-Albrechts-University of Kiel Institute of Immunology, University Hospital Schleswig-Holstein
Hypothesis
CD95 acts as a dual-function receptor that can either promote or inhibit T cell activation depending on the context.
Conclusion
CD95 can enhance T cell activation at low doses but inhibit it at high doses, highlighting its complex role in immune responses.
Supporting Evidence
- CD95 engagement can silence T cells at high doses.
- Low doses of CD95 agonists enhance T cell activation and proliferation.
- CD95 acts as a costimulatory receptor in T cell activation.
- High levels of CD95L can lead to T cell apoptosis.
- CD95 signaling outcomes depend on the activation state of T cells.
Takeaway
CD95 is like a switch for T cells; sometimes it helps them grow and fight, and other times it tells them to stop working.
Methodology
The study reviews recent findings on CD95 signaling in T cells, focusing on its costimulatory effects and the dose-dependent nature of its signaling.
Limitations
The study primarily discusses findings from mouse models and may not fully translate to human T cell responses.
Digital Object Identifier (DOI)
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