Aurora-A Interacts with AP-2α and Down Regulates Its Transcription Activity
2011
Aurora-A Regulates AP-2α Activity
publication
Evidence: moderate
Author Information
Author(s): Zou Lihui, Sun Yimin, Wang Mingrong, Zhan Qimin
Primary Institution: State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hypothesis
How does Aurora-A affect the transcription activity of AP-2α?
Conclusion
Aurora-A downregulates AP-2α transcription activity and protein stability, contributing to tumorigenesis.
Supporting Evidence
- Aurora-A overexpression suppresses AP-2α transcription activity.
- AP-2α protein levels are lower in cells with high Aurora-A.
- Aurora-A enhances the degradation of AP-2α through proteasomal pathways.
- The downregulation of AP-2α by Aurora-A occurs independently of p53.
Takeaway
Aurora-A is a protein that can make another protein, AP-2α, less active, which might help cancer grow.
Methodology
The study used transcription factors array and mRNA expression profiling array to analyze the effect of Aurora-A on gene transcription.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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