Loss of heterozygosity at 7p in Wilms' tumour development
2000
Loss of Heterozygosity in Wilms' Tumour Development
Sample size: 77
publication
Evidence: moderate
Author Information
Author(s): Powlesland R M, Charles A K, Malik K T A, Reynolds P A, Pires S, Boavida M, Brown K W
Primary Institution: CLIC Research Unit, University of Bristol
Hypothesis
Chromosome 7p alterations are implicated in the development of Wilms' tumour.
Conclusion
The study found that loss of heterozygosity at chromosome 7p is present in a subset of Wilms' tumours, suggesting a potential tumour suppressor gene in that region.
Supporting Evidence
- The study found loss of heterozygosity in seven out of 77 informative Wilms' tumours.
- The common region of loss of heterozygosity was identified between 7p15 and 7p22.
- Four Wilms' tumours with 7p loss of heterozygosity had other genetic changes.
- Analysis of associated lesions revealed a cystic nephroma-like area with 7p loss of heterozygosity.
Takeaway
Researchers looked at a part of chromosome 7 in kids with a type of kidney cancer called Wilms' tumour and found some changes that might help explain how the cancer develops.
Methodology
Used polymorphic microsatellite markers to study loss of heterozygosity in Wilms' tumours.
Digital Object Identifier (DOI)
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