MicroRNA MTCO3P38 Inhibits the TMOD1/MMP13 Pathway to Alleviate the Progression of Hepatocellular Carcinoma
2025
MicroRNA MTCO3P38 and Its Role in Liver Cancer
Sample size: 24
publication
Evidence: high
Author Information
Author(s): Wu Ping, Li Guoyuan, Guo Deliang, Guo Tao, Chai Chengwei
Primary Institution: Guangzhou Women and Children's Medical Center, Guangzhou Medical University
Hypothesis
MiR-MTCO3P38 inhibits hepatocellular carcinoma progression by targeting the TMOD1/MMP13 pathway.
Conclusion
MiR-MTCO3P38 suppresses the TMOD1/MMP13 pathway to alleviate HCC progression.
Supporting Evidence
- MiR-MTCO3P38 inhibits the migration and invasion of HCC cells.
- TMOD1 was identified as the target gene of miR-MTCO3P38.
- Overexpression of TMOD1 reversed the inhibitory effects of miR-MTCO3P38 on tumor growth.
- MiR-MTCO3P38 downregulated MMP13 expression.
- High expression of miR-MTCO3P38 was associated with reduced tumor size in mice.
Takeaway
A tiny molecule called miR-MTCO3P38 helps stop liver cancer from growing by blocking a specific pathway.
Methodology
The study used in vitro and in vivo experiments to analyze the effects of miR-MTCO3P38 on HCC cells and tumor growth.
Participant Demographics
Female BALB/c nude mice, 6-8 weeks old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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