Absence of human herpes virus-8 (HHV8) in nephrogenic systemic fibrosis
2008
Study on HHV8 and Nephrogenic Systemic Fibrosis
Sample size: 2
publication
Evidence: low
Author Information
Author(s): Patrick J O'Donnell, Wayne H Duke, Liron Pantanowitz
Primary Institution: Baystate Medical Center, Tufts University School of Medicine
Hypothesis
Does HHV8 play a role in the pathogenesis of nephrogenic systemic fibrosis?
Conclusion
This finding negates a role for HHV8 in the pathogenesis of nephrogenic systemic fibrosis.
Supporting Evidence
- Skin lesions from two male NSF patients were negative for HHV8.
- Positive immunostaining for HHV8 is highly sensitive and specific for diagnosing HHV8-infected tissue.
Takeaway
The study looked at two patients with a skin disease and found no evidence of a virus called HHV8 being involved.
Methodology
Immunohistochemical analysis of skin lesions from two male patients.
Limitations
The study is limited to only two patients.
Participant Demographics
Two male patients aged 73 and 78 with chronic renal insufficiency.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website