Impact of Abnormal Glucose Regulation on Heart Attack Recovery
Author Information
Author(s): Knudsen Eva C, Seljeflot Ingebjørg, Abdelnoor Michael, Eritsland Jan, Mangschau Arild, Müller Carl, Arnesen Harald, Andersen Geir Ø
Primary Institution: Oslo University Hospital, Ullevål, Oslo, Norway
Hypothesis
Does abnormal glucose regulation affect long-term prognosis in patients with ST-elevation myocardial infarction (STEMI) without known diabetes?
Conclusion
Patients with STEMI and abnormal glucose regulation have an excellent long-term prognosis, regardless of their glucose status.
Supporting Evidence
- 47% of patients were diagnosed with abnormal glucose regulation in-hospital.
- 25.9% of patients experienced a new clinical event during follow-up.
- The study included 224 patients with a median follow-up of 33 months.
Takeaway
This study looked at heart attack patients who didn't know they had diabetes. It found that their long-term health was good, no matter what their blood sugar levels were.
Methodology
Patients were followed for clinical events after being classified by a standardized oral glucose tolerance test (OGTT) at two time points.
Potential Biases
Potential bias due to exclusion of patients with known diabetes and those who were hemodynamically unstable.
Limitations
The study may have a selection bias as it excluded unstable patients and those with severe comorbidities.
Participant Demographics
Patients were primarily younger, with a median age of 58 years, and included both men and women.
Statistical Information
P-Value
p=0.4 for in-hospital classification and p=0.3 for three-month follow-up classification.
Confidence Interval
95% CI 0.48-1.38 for in-hospital classification and 95% CI 0.34-1.36 for three-month follow-up.
Digital Object Identifier (DOI)
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