Comparing Ranitidine and Pantoprazole for Gastric pH in Surgery
Author Information
Author(s): Tapas Bhattacharyya, Debabrata Sarbapalli, Ranabir Pal, Ujjal Kar, Sumit Kundu, Kanak Kanti Kundu, Forhad Akhtar
Primary Institution: Institute of Postgraduate Medical Education & Research (IPGME&R), Kolkata, India
Hypothesis
The study aims to compare the effects of preoperative oral ranitidine versus pantoprazole on gastric pH in elective surgery.
Conclusion
Ranitidine is more effective than pantoprazole in raising gastric pH to prevent aspiration pneumonitis.
Supporting Evidence
- Ranitidine significantly raised gastric pH compared to placebo and pantoprazole.
- Mean preoperative gastric pH values were significantly lower in the placebo group.
- Statistical analysis showed no significant difference in gastric pH trends for the placebo and pantoprazole groups.
Takeaway
This study looked at how two medicines, ranitidine and pantoprazole, help keep the stomach less acidic before surgery. Ranitidine worked better.
Methodology
A randomized, controlled, single-blind study with 120 participants divided into three groups receiving placebo, ranitidine, or pantoprazole.
Potential Biases
Individual variations in gastric juice or acid output were uncontrollable factors.
Limitations
The study used otherwise healthy participants and surrogate endpoints, which may weaken the clinical relevance.
Participant Demographics
Participants were aged 18-60 years, of either sex, and classified as ASA physical status I and II.
Statistical Information
P-Value
P<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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