Input Noise in Gene Regulation
2008
The Role of Input Noise in Gene Regulation
publication
Evidence: moderate
Author Information
Author(s): Tkačik Gašper, Gregor Thomas, Bialek William
Primary Institution: Princeton University
Hypothesis
How does input noise affect transcriptional regulation?
Conclusion
Input noise significantly influences the reliability of gene expression, particularly in the early Drosophila embryo.
Supporting Evidence
- Gene expression levels fluctuate even under constant external conditions.
- Input noise has a clear signature that peaks at intermediate transcription factor concentrations.
- Recent experiments on Drosophila embryos support the predicted signatures of input noise.
Takeaway
Sometimes, the noise in how genes are turned on and off can make it hard for cells to know what to do. This study looks at how that noise happens and what it means for how genes work.
Methodology
The study analyzes the effects of random arrival times and binding of transcription factors on gene expression noise.
Limitations
The analysis may be obscured by experimental limitations and conventional data plotting methods.
Digital Object Identifier (DOI)
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