Acute Kidney Injury in Children with COVID-19
Author Information
Author(s): Yazılıtaş Fatma, Çakıcı Evrim Kargın, Güngör Tülin, Karakaya Deniz, Çelikkaya Evra, Şen Zeynep Savaş, Gümüşer Rüveyda, Tanır Naciye Gönül, Bülbül Mehmet
Primary Institution: Dr Sami Ulus Kadin Dogum Cocuk Sagligi ve Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey
Hypothesis
What are the risk factors contributing to hospitalised and outpatient paediatric COVID-19-associated acute kidney injury?
Conclusion
Children with COVID-19 are at risk for acute kidney injury, especially those with comorbidities and certain symptoms.
Supporting Evidence
- Acute kidney injury was observed in 3.7% of outpatients and 23.9% of hospitalised patients.
- Multivariate analysis identified several independent predictors of AKI including age below 12 months and presence of comorbidities.
- Patients with AKI had significantly higher levels of inflammatory markers compared to those without AKI.
- AKI was associated with longer hospital stays and higher rates of admission to the pediatric intensive care unit.
Takeaway
This study found that kids with COVID-19 can get sick kidneys, especially if they have other health problems or certain symptoms.
Methodology
A retrospective observational study was conducted on patients aged 1 month to 18 years with diagnosed COVID-19-associated AKI.
Potential Biases
Potential bias due to the observational design and exclusion of patients without prior creatinine levels.
Limitations
The study's retrospective nature and lack of baseline serum creatinine measurements for many patients limit the generalizability of the findings.
Participant Demographics
Patients aged 1 month to 18 years, with a median age of 31.7 months.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website