Diethyl 2-{4-diethylamino-2-[(dimethylcarbamothioyl)oxy]benzylidene}malonate
2011
Fluorescent Probe for Hypochlorous Acid
publication
Evidence: moderate
Author Information
Author(s): Sun Dan, Fan Xiao-Xing, Yang Shi-Yao, Zheng Hong
Primary Institution: Xiamen University
Hypothesis
Can the synthesized compound serve as a sensitive fluorescent probe for hypochlorous acid?
Conclusion
The title compound can react with hypochlorous acid, resulting in a significant increase in fluorescence.
Supporting Evidence
- The compound exhibits a fluorescence emission at 509 nm with maximum excitation at 403 nm.
- Single crystals were obtained by slow evaporation of a dichloromethane/petroleum ether solution.
- The structure shows strong intramolecular charge transfer effects.
Takeaway
The researchers made a special chemical that lights up when it meets a certain substance called hypochlorous acid, which is important for studying biology.
Methodology
The compound was synthesized through a two-step chemical reaction and its structure was determined using X-ray crystallography.
Digital Object Identifier (DOI)
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