Caspase-3-like activity determines the type of cell death following ionizing radiation in MOLT-4 human leukaemia cells
2000
Caspase-3-like Activity and Cell Death in Leukaemia Cells
publication
Author Information
Author(s): Coelho D, Holl V, Weltin D, Lacornerie T, Magnenet P, Dufour P, Bischoff P
Primary Institution: Laboratoire de Cancérologie Expérimentale et de Radiobiologie, IRCAD, Hôpitaux Universitaires, Strasbourg, France
Hypothesis
Inhibition of caspase-3-like activity affects the type of cell death in irradiated MOLT-4 human leukaemia cells.
Conclusion
Inhibiting caspase-3-like activity leads to necrotic cell death instead of apoptosis in irradiated MOLT-4 cells.
Supporting Evidence
- Inhibition of caspase-3-like activity prevents classical apoptosis markers in irradiated cells.
- Irradiated cells treated with the inhibitor showed characteristics of necrotic cell death.
Takeaway
When certain proteins are blocked, cancer cells can die in a different way when exposed to radiation, which might help in treating cancer better.
Methodology
MOLT-4 cells were treated with a caspase-3 inhibitor and exposed to X-rays at doses of 1 to 4 Gy.
Digital Object Identifier (DOI)
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