Insulin as a primary autoantigen for type 1A diabetes
2005
Insulin as a Primary Autoantigen for Type 1A Diabetes
publication
Evidence: moderate
Author Information
Author(s): J. M. Jasinski, G. S. Eisenbarth
Primary Institution: Barbara Davis Center for Childhood Diabetes
Hypothesis
Insulin is a primary autoantigen for type 1 diabetes.
Conclusion
Type 1A diabetes is a complex disorder involving multiple genes and environmental influences, with autoantibodies preceding overt disease.
Supporting Evidence
- Autoantibodies can be detected years before overt disease is diagnosed.
- Individuals expressing multiple autoantibodies have a high risk of developing diabetes.
- Insulin peptide B:9-23 can be used to induce insulin autoantibodies in animal models.
Takeaway
Type 1A diabetes happens when the body attacks its own insulin-producing cells, and scientists think insulin itself is a big part of this problem.
Methodology
The review discusses various studies and experiments involving animal models and human data related to insulin and autoimmunity.
Limitations
The complexity of type 1A diabetes makes it likely that there are many alternative pathways leading to the disease.
Digital Object Identifier (DOI)
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