Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results
2000
Bisphosphonates in Cancer Treatment
publication
Evidence: moderate
Author Information
Author(s): Diel I J, Mundy G R
Primary Institution: University of Heidelberg
Hypothesis
Do bisphosphonates have a prophylactic effect against bone metastasis in cancer patients?
Conclusion
Bisphosphonates may help reduce the occurrence of new skeletal metastases in patients with advanced breast cancer.
Supporting Evidence
- Animal models suggest bisphosphonates can prevent bone metastasis.
- Preliminary clinical trials show bisphosphonates reduce new skeletal metastases in advanced breast cancer patients.
Takeaway
Bisphosphonates are medicines that might help stop cancer from spreading to the bones.
Methodology
The study reviews animal models and preliminary clinical trials regarding bisphosphonate treatment.
Digital Object Identifier (DOI)
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