1,2-Dithiol-3-thione and dithioester analogues: potential radioprotectors
1990
Potential Radioprotectors from Dithiol Compounds
publication
Evidence: moderate
Author Information
Author(s): B.A. Teicher, J. Stemwedel, T.S. Herman, P.K. Ghoshal, A. Rosowsky
Primary Institution: Dana-Farber Cancer Institute
Hypothesis
Can 1,2-dithiol-3-thione and dithioester compounds act as effective radioprotectors in EMT6 cells?
Conclusion
Several 1,2-dithiol-3-thione and dithioester compounds were found to be effective radioprotectors in vitro.
Supporting Evidence
- 1,2-dithiol-3-thiones were generally more cytotoxic than dithioesters.
- The 5-(2-thienyl)-1,2-dithiol-3-thione produced a radiation protection factor of 2.7.
- Several dithioesters showed radiation protection factors ranging from 2.6 to 2.9.
Takeaway
Some special chemicals can help protect cells from radiation damage, which is important for cancer treatment.
Methodology
The study tested various 1,2-dithiol-3-thione and dithioester compounds for their radioprotective effects on EMT6 cells in vitro.
Limitations
The study was conducted in vitro, and the effects in vivo are still being investigated.
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