Foxp3 and IL-10 Levels in Post Kala Azar Dermal Leishmaniasis Patients
Author Information
Author(s): Katara Gajendra Kumar, Ansari Nasim Akhtar, Verma Sandeep, Ramesh V., Salotra Poonam
Primary Institution: Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India
Hypothesis
The study investigates the correlation of natural regulatory T cell markers and IL-10 with parasite load in PKDL lesion tissues.
Conclusion
The study found that elevated levels of nTreg cells and IL-10 in PKDL lesions correlate with higher parasite burden.
Supporting Evidence
- Elevated mRNA levels of nTreg markers were found in pre-treatment PKDL cases compared to controls.
- Foxp3, CD25, and IL-10 mRNA levels directly correlated with parasite load in lesion tissues.
- Post-treatment, mRNA levels of nTreg markers and IL-10 were significantly reduced.
Takeaway
This study shows that certain immune cells and a molecule called IL-10 are linked to how much parasite is in the skin of people with a specific disease called PKDL.
Methodology
The study involved ex-vivo mRNA and protein analysis of nTreg markers and IL-10 levels in lesion tissues of PKDL patients.
Participant Demographics
{"age_range":"19–52","mean_age":27.72,"sex_ratio":"22 males, 3 females"}
Statistical Information
P-Value
0.0009
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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