High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China
Author Information
Author(s): Yu Fangyou, Chen Qiang, Yu Xiaojun, Li Qiaoqiao, Ding Baixing, Yang Lehe, Chen Cong, Qin Zhiqiang, Parsons Chris, Zhang Xueqing, Huang Jinwei, Luo Yun, Wang Liangxing, Pan Jingye
Primary Institution: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
Hypothesis
The study aimed to investigate the frequency of antimicrobial resistance and cephalosporin resistance genes within S. enterica isolates from pediatric inpatients with diarrhea.
Conclusion
The study found significant multi-drug resistance and a high prevalence of extended-spectrum beta lactamases among S. enterica Typhimurium isolates from children in China.
Supporting Evidence
- A large proportion of S. enterica Typhimurium isolates were resistant to multiple antimicrobial agents.
- 79% of S. enterica Typhimurium isolates were positive for blaTEM-1b and resistant to ampicillin.
- The study identified the first occurrence of blaCTX-M-55 in Salmonella spp.
Takeaway
Doctors found that many sick kids in China had a type of bacteria that didn't respond to common medicines, making it harder to treat their diarrhea.
Methodology
The study collected 62 S. enterica Typhimurium isolates from stool samples of pediatric patients and tested their antimicrobial susceptibility using disk diffusion and PCR methods.
Limitations
The study focused only on bacterial isolates and did not include other potential pathogens.
Participant Demographics
Participants were pediatric inpatients aged 39 days to 5 years, with 34 males and 28 females.
Digital Object Identifier (DOI)
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