Switching to Granisetron After Ondansetron Failure in Chemotherapy Patients
Author Information
Author(s): de Wit R, de Boer A C, vd Linden G H M, Stoter G, Sparreboom A, Verweij J
Primary Institution: Rotterdam Cancer Institute and University Hospital Rotterdam, IJsselland Hospital Rotterdam, Albert Schweitzer Hospital Dordrecht, The Netherlands
Hypothesis
Is there a benefit to switching from ondansetron to granisetron in patients who fail ondansetron during chemotherapy?
Conclusion
Switching to granisetron after failure on ondansetron significantly improves patient outcomes.
Supporting Evidence
- 21 patients received ondansetron and 19 received granisetron.
- 9 out of 19 patients who switched to granisetron achieved complete protection.
- Only 1 out of 21 patients continuing ondansetron achieved complete protection.
Takeaway
If a medicine doesn't work for you, trying a different one might help, and that's what this study found.
Methodology
A randomized double-blind trial comparing granisetron plus dexamethasone to continued ondansetron plus dexamethasone.
Participant Demographics
Patients undergoing highly emetogenic chemotherapy.
Statistical Information
P-Value
0.005
Statistical Significance
p=0.005
Digital Object Identifier (DOI)
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