Dioscorea Phytocompounds Enhance Immune Cell Growth and Bone Marrow Regeneration
Author Information
Author(s): Su Pei-Fen, Li Chin-Jin, Hsu Chih-Chien, Benson Spencer, Wang Sheng-Yang, Aravindaram Kandan, Chan Sunney I., Wu Shih-Hsiung, Yang Feng-Ling, Huang Wen-Ching, Shyur Lie-Fen, Yang Ning-Sun
Primary Institution: Agricultural Biotechnology Research Center, Academia Sinica
Hypothesis
Can Dioscorea tuber extracts improve immune cell proliferation and bone marrow regeneration in mice treated with chemotherapy?
Conclusion
Dioscorea tuber extract significantly enhances the proliferation of immune cells and aids in the recovery of bone marrow in chemotherapy-treated mice.
Supporting Evidence
- DsCE-II significantly increased splenocyte proliferation compared to controls.
- Co-treatment with IL-2 and DsCE-II resulted in a 3.2-fold increase in cell proliferation.
- DsCE-II improved recovery of bone marrow cells in chemotherapy-treated mice.
- CFU-GM cell populations recovered significantly in mice treated with DsCE-II.
Takeaway
This study shows that a plant called Dioscorea can help mice recover their immune cells and bone marrow after chemotherapy, which is usually very damaging.
Methodology
Mice were treated with chemotherapy and then given Dioscorea extracts to assess their effects on immune cell proliferation and bone marrow recovery.
Potential Biases
Potential bias in the selection of plant extracts and the specific conditions of the animal model used.
Limitations
The study was conducted on mice, and further clinical trials are needed to confirm the effects in humans.
Participant Demographics
Female BALB/c mice aged 8–12 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website