CD73: agent development potential and its application in diabetes and atherosclerosis
2024
CD73 and Its Role in Diabetes and Atherosclerosis
publication
Evidence: moderate
Author Information
Author(s): Liu Dan, Zhao Jingjing, Li Ling, Wang Jie, Wang Chao, Wu Yudong, Huang Yucun, Xing Dongming, Chen Wujun
Hypothesis
What is the role of CD73 in diabetes and atherosclerosis?
Conclusion
CD73 may serve as a potential biomarker and therapeutic target for diabetes and atherosclerosis.
Supporting Evidence
- CD73 plays a protective role in diabetes and atherosclerosis.
- CD73 can have both pro-inflammatory and anti-inflammatory effects depending on the context.
- Agents that upregulate CD73 have been shown to decrease the development of diabetes and atherosclerosis.
- CD73 expression changes with age, affecting its role in atherosclerosis.
Takeaway
CD73 is a protein that can help protect against diabetes and heart disease, but it can also have harmful effects as we age.
Methodology
This mini-review summarizes current knowledge on CD73's role in diabetes and atherosclerosis, including its effects and potential therapeutic agents.
Limitations
The review highlights the need for more studies to confirm the role of CD73 in atherosclerosis and diabetes.
Digital Object Identifier (DOI)
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