SOFA Score and Acute Kidney Injury in Diabetic Ketoacidosis
Author Information
Author(s): Hua Yiming, Ding Ning, Jing Huaizhi, Xie Yifei, Wu Hao, Wu Yue, Lan Beidi
Primary Institution: Xi’an Jiaotong University
Hypothesis
The study aims to investigate the relationship between SOFA scores and the incidence of acute kidney injury in patients with diabetic ketoacidosis.
Conclusion
A high SOFA score is an independent risk predictor for acute kidney injury, renal replacement therapy, and in-hospital mortality in patients with diabetic ketoacidosis.
Supporting Evidence
- Patients with higher SOFA scores had a 62.3% incidence of acute kidney injury compared to 14.2% in those with lower scores.
- All patients requiring renal replacement therapy were from the higher SOFA score group.
- The in-hospital mortality rate was significantly higher in the higher SOFA score group at 15.5%.
Takeaway
The SOFA score helps doctors figure out how likely it is that a patient with diabetic ketoacidosis will have kidney problems.
Methodology
The study used the MIMIC-IV database to analyze patients with diabetic ketoacidosis, employing Kaplan–Meier survival analysis, Cox proportional hazards models, and logistic regression models.
Potential Biases
Potential biases due to the limitations of the MIMIC database and lack of socioeconomic data.
Limitations
The study is observational and cannot establish causality; it only recorded initial SOFA scores at admission without tracking changes over time.
Participant Demographics
Of the 626 patients, 335 (53%) were male, with a mean age of 60.25 years in the higher SOFA score group.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 1.228–1.473
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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