Asiatic Acid Inhibits Pro-Angiogenic Effects of VEGF and Human Gliomas in Endothelial Cell Culture Models
2011
Asiatic Acid's Anti-Angiogenic Effects on Gliomas
publication
Evidence: high
Author Information
Author(s): Kavitha Chandagirikoppal V., Chapla Agarwal, Rajesh Agarwal, Gagan Deep
Primary Institution: University of Colorado Denver
Hypothesis
Asiatic Acid (AsA) inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models.
Conclusion
Asiatic Acid shows strong anti-angiogenic potential and may be useful against malignant gliomas.
Supporting Evidence
- Asiatic Acid inhibits HUVEC growth and induces apoptosis.
- It disrupts capillary tube formation in endothelial cells.
- Asiatic Acid reduces VEGF levels in glioma cells.
- It inhibits glioma cell-induced chemotactic motility of endothelial cells.
- Asiatic Acid shows dose-dependent anti-angiogenic efficacy.
Takeaway
Asiatic Acid can help stop the growth of bad cells in the brain by blocking the blood supply they need to grow.
Methodology
The study used human umbilical vein endothelial cells (HUVEC) and human brain microvascular endothelial cells (HBMEC) to test the effects of Asiatic Acid on cell growth, apoptosis, migration, and tube formation.
Statistical Information
P-Value
p≤0.001
Statistical Significance
p≤0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website