CD55 is over-expressed in the tumour environment
2001
CD55 Over-Expression in Tumors
publication
Author Information
Author(s): Li L, Spendlove I, Morgan J, Durrant L G
Primary Institution: CRC Academic Unit of Clinical Oncology, University of Nottingham
Hypothesis
The study investigates the expression of CD55 in the tumor environment compared to normal cells.
Conclusion
Tumor cells show significantly higher levels of CD55 expression, suggesting its potential as a target for cancer imaging and therapy.
Supporting Evidence
- Tumor cells showed a 4–100-fold increase in CD55 cell surface expression compared to normal cells.
- High expression of CD55 was observed in the stroma of colorectal tumors.
- Tumor cell lines deposit CD55 into their extracellular matrix in proportion to their cell surface expression.
- ECM from HUVEC cells contained large amounts of CD55 despite low cell surface expression.
Takeaway
CD55 is a protein that helps protect cancer cells, and it is found in much higher amounts in tumors than in normal cells.
Methodology
Quantitative expression of CD55 was studied using immunohistochemical staining and measurement of extracellular CD55 production by different cell types.
Digital Object Identifier (DOI)
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