Th17 Cells and Their Role in Tumor Control in Primary Intraocular Lymphoma
Author Information
Author(s): Galand Claire, Donnou Sabrina, Crozet Lucile, Brunet Séverine, Touitou Valérie, Ouakrim Hanane, Fridman Wolf Herman, Sautès-Fridman Catherine, Fisson Sylvain
Primary Institution: Institut National de la Santé et de la Recherche Médicale, UMRS872, Centre de Recherche des Cordeliers, Paris, France
Hypothesis
Do Th17 cells and their related cytokines play a role in controlling tumor progression in primary intraocular lymphoma?
Conclusion
Th17 cells infiltrate the tumor microenvironment and may help counteract tumor progression through IL-21 production.
Supporting Evidence
- Th17 cells were found in the tumor microenvironment of primary intraocular lymphoma.
- IL-17A production by T cells was negatively correlated with tumor burden.
- IL-21, produced by Th17 cells, inhibited tumor cell proliferation in vitro.
Takeaway
Th17 cells are special immune cells that can help fight certain tumors, and they make a substance called IL-21 that might stop tumors from growing.
Methodology
The study used a murine model of primary intraocular lymphoma to analyze the presence and effects of Th17 cells and their cytokines.
Limitations
The study was conducted in a murine model, which may not fully replicate human disease.
Participant Demographics
Female BALB/c ByJ mice, aged 6 to 8 weeks.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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