Demographic Variation in Adult Glioma Incidence in the U.S.
Author Information
Author(s): Robert Dubrow, Amy S. Darefsky
Primary Institution: Yale School of Public Health, Yale School of Medicine
Hypothesis
Race/ethnic group, sex, age, and/or calendar period variation in adult glioma incidence differs between glioblastoma and non-glioblastoma subtypes.
Conclusion
There are significant differences in the incidence rates of glioblastoma and non-glioblastoma based on age, race/ethnic group, and sex, suggesting different underlying mechanisms for these subtypes.
Supporting Evidence
- The incidence rate of GBM increases steeply with age, while non-GBM increases more slowly.
- Blacks, Asians/Pacific Islanders, and American Indians/Alaskan Natives have lower incidence rates compared to non-Hispanic Whites.
- Males have a higher incidence rate than females for both GBM and non-GBM.
Takeaway
This study found that different types of brain tumors affect people differently based on their age, race, and gender.
Methodology
Data from the SEER Program for 1992-2007 was analyzed, comparing 15,088 GBM cases with 9,252 non-GBM cases using Poisson regression.
Potential Biases
Potential selection bias due to differences in diagnosis based on demographic factors.
Limitations
The study could not classify non-GBM tumors into specific categories and may have selection bias due to diagnostic variability.
Participant Demographics
Adults aged 30-69 years, with a significant representation of non-Hispanic Whites, Blacks, Asians/Pacific Islanders, and American Indians/Alaskan Natives.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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