Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire
2025

Understanding Topical Steroid Withdrawal in Atopic Dermatitis

Sample size: 82 publication 10 minutes Evidence: moderate

Author Information

Author(s): ALSTERHOLM Mikael, AF KLINTEBERG Maja, VRANG Sophie, SIGURDARDOTTIR Gunnthorunn, SANDSTRÖM FALK MariHelen, SHAYESTEH Alexander

Primary Institution: Karolinska Institutet, University of Gothenburg, Umeå University, Linköping University

Hypothesis

What are the patient-reported characteristics of topical steroid withdrawal in individuals with atopic dermatitis?

Conclusion

The study provides a detailed characterization of symptoms attributed to topical steroid withdrawal, highlighting significant morbidity among affected individuals.

Supporting Evidence

  • Participants reported symptoms like pruritus, sleep disturbance, and anxiety.
  • Most participants defined TSW as dependency on topical glucocorticoids.
  • Recurring episodes of symptoms attributed to TSW were common among participants.

Takeaway

Some people feel really bad after stopping their skin cream, and this study helps us understand what they go through.

Methodology

An observational cross-sectional study using a questionnaire distributed in a Swedish TSW-themed Facebook group.

Potential Biases

Potential selection biases due to the recruitment method and self-diagnosis of TSW.

Limitations

The study relied on self-reported data and did not confirm atopic dermatitis diagnoses through physical examination.

Participant Demographics

Most participants were female (95%), aged 18-39 years (74%), and self-diagnosed with TSW (84%).

Digital Object Identifier (DOI)

10.2340/actadv.v105.40187

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