Smartphone-Based Immunosensor for Cancer Detection
Author Information
Author(s): Khonyoung Supada, Mangkronkaew Praphatsorn, Klayprasert Puttaporn, Puangpila Chanida, Palanisami Muthukumaran, Arivazhagan Mani, Jakmunee Jaroon
Primary Institution: Thammasat University, Thailand
Hypothesis
Can a smartphone-based, label-free electrochemical immunosensor effectively detect carcinoembryonic antigen (CEA) in serum samples?
Conclusion
The developed immunosensor can accurately detect low levels of CEA in serum, making it a promising tool for early cancer diagnosis.
Supporting Evidence
- The immunosensor showed a linear detection range of 0.1–5.0 ng mL−1 for CEA.
- It achieved a low detection limit of 0.08 ng mL−1, which is below the normal CEA level.
- The sensor demonstrated high selectivity and reproducibility in detecting CEA.
- Recovery rates for CEA detection in serum samples ranged from 101% to 112%.
Takeaway
This study created a small device that can quickly check for cancer markers in blood using a smartphone, which is easy to use and doesn't need extra labels.
Methodology
The immunosensor was constructed using a layer-by-layer assembly of nanostructured materials on a screen-printed carbon electrode, allowing for direct detection of CEA without additional labeling.
Limitations
The immunosensor currently detects only one biomarker, which may limit its application in comprehensive cancer diagnostics.
Statistical Information
P-Value
0.08 ng mL−1
Digital Object Identifier (DOI)
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