Soluble interleukin-2 receptors in ulcerative colitis
Author Information
Author(s): O. H. Nielsen, J. Brynskov
Primary Institution: University of Copenhagen
Hypothesis
Is serum concentration of sIL-2R a marker of disease activity in patients with ulcerative colitis?
Conclusion
Increased serum sIL-2R concentrations in ulcerative colitis suggest enhanced T-cell activation.
Supporting Evidence
- Serum sIL-2R concentrations were significantly increased in UC patients compared to controls.
- Median sIL-2R concentration was 150 pg/ml in active UC patients.
- Patients in remission also had elevated sIL-2R levels.
Takeaway
The study found that people with ulcerative colitis have higher levels of a certain protein in their blood, which might show how active their disease is.
Methodology
Serum sIL-2R concentrations were measured using an enzyme-linked immunosorbent assay (ELISA).
Limitations
The general diagnostic value of sIL-2R levels is limited due to overlap between different disease stages and controls.
Participant Demographics
27 patients with ulcerative colitis (17 women, 10 men; median age 40 years) and 13 healthy volunteers (10 women, 3 men; median age 34 years).
Statistical Information
P-Value
p < 0.01
Statistical Significance
p<0.01
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