The Dynamics of Human Body Weight Change
2008

Understanding Human Body Weight Change

publication Evidence: moderate

Author Information

Author(s): Chow Carson C., Hall Kevin D.

Primary Institution: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Hypothesis

An imbalance between energy intake and energy expenditure will lead to a change in body weight and body composition.

Conclusion

A mathematical model can capture the long-term dynamics of human weight change, revealing important implications for obesity treatment.

Supporting Evidence

  • The study shows that body composition can exist at an infinite number of possible states under certain conditions.
  • Mathematical modeling provides a general description of how body weight will change over time.
  • The existing experimental data cannot distinguish between two classes of body composition models.

Takeaway

This study shows that how our body weight changes depends on the food we eat and how much energy we use, and it can be modeled mathematically.

Methodology

The study used mathematical modeling to analyze the dynamics of body composition and mass change based on energy flux balances.

Limitations

Existing data are insufficient to distinguish between different model classes of body weight dynamics.

Digital Object Identifier (DOI)

10.1371/journal.pcbi.1000045

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