Studying Sex Differences in Pain through Proteomics
Author Information
Author(s): Barry Allison M, Sondermann Julia R, Lesnak Joseph B, Xian Feng, Franco-Enzástiga Úrzula, O’Brien Jayden A, Varela David Gomez, Schackmuth Morgan K, Shiers Stephanie, Price Theodore J, Schmidt Manuela
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Is TNFα signalling a relevant sexually dimorphic pathway in chronic pain disorders?
Conclusion
The study found that TNFα signalling is a significant pathway that differs between sexes in the context of chronic pain.
Supporting Evidence
- The study expanded the omics landscape in the peripheral nervous system.
- It validated findings against tissue-specific differences between nerve and dorsal root ganglia.
- Multi-omic analyses were combined with in vitro functional support to examine sex differences.
Takeaway
The researchers looked at how men and women experience pain differently at a molecular level and found that a specific pathway is important for understanding these differences.
Methodology
The study used quantitative proteomics and data-independent acquisition mass spectrometry to analyze protein differences in human dorsal root ganglia.
Digital Object Identifier (DOI)
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