Gene Variants and Colorectal Cancer Risk in Women
Author Information
Author(s): Lin Jennifer H, Manson JoAnn E, Kraft Peter, Cochrane Barbara B, Gunter Marc J, Chlebowski Rowan T, Zhang Shumin M
Primary Institution: Brigham and Women's Hospital and Harvard Medical School
Hypothesis
Inherited variation in sex-hormone genes may affect colorectal cancer risk.
Conclusion
The study suggests a weak association between certain gene variants and colorectal cancer risk in women.
Supporting Evidence
- The study included 427 women with colorectal cancer and 871 matched controls.
- Unconditional logistic regression was used to estimate odds ratios.
- Variants in CYP17A1 and CYP19A1 were suggestively associated with colorectal cancer risk.
Takeaway
This study looked at how certain genes related to hormones might affect the risk of getting colorectal cancer in women. They found some links, but they weren't very strong.
Methodology
A case-control study evaluated SNPs in hormone-related genes among women with colorectal cancer and matched controls.
Limitations
The study may not cover all genetic variations and had limited power for subgroup analyses.
Participant Demographics
Women of European ancestry, aged 50 to 79 years.
Statistical Information
P-Value
0.07
Confidence Interval
1.09-1.78
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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