Antifungal Activity of Brazilian Propolis Microparticles against Yeasts from Vulvovaginal Candidiasis
Author Information
Author(s): Kelen Fátima Dalben Dota, Consolaro Marcia Edilaine Lopes, Svidzinski Terezinha Inez Estivalet, Bruschi Marcos Luciano
Primary Institution: State University of Maringa, Parana, Brazil
Hypothesis
The study aims to evaluate the in vitro antifungal activity of Brazilian propolis microparticles against clinical yeast isolates associated with vulvovaginal candidiasis.
Conclusion
Propolis microparticles showed effective antifungal activity against both C. albicans and non-C. albicans yeast isolates, suggesting their potential use in treating vulvovaginal candidiasis.
Supporting Evidence
- All yeast isolates were inhibited by propolis ethanol extract and microparticles.
- Propolis microparticles showed a higher total phenolic content compared to the ethanol extract.
- Resistance to standard antifungal drugs was observed in some yeast isolates.
Takeaway
This study found that a natural substance from bees, called propolis, can help fight infections caused by yeast in women's bodies.
Methodology
The study involved testing 89 yeast strains from patients with vulvovaginal candidiasis using the broth microdilution method to determine the minimum inhibitory concentration of propolis microparticles and standard antifungal drugs.
Limitations
The study primarily focused on in vitro results, which may not fully translate to clinical efficacy in vivo.
Participant Demographics
Yeast isolates were obtained from vaginal exudates of patients with vulvovaginal candidiasis.
Digital Object Identifier (DOI)
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