Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
2001
Fluoropyrimidine Sensitivity in Breast Cancer Cells
publication
Author Information
Author(s): Cuq P, Rouquet C, Evrard A, Ciccolini J, Vian L, Cano J-P
Primary Institution: Laboratoire de Toxicologie du Médicament, Faculté de Pharmacie, Montpellier, France
Hypothesis
Does overexpression of uridine phosphorylase increase the sensitivity of MCF-7 breast cancer cells to fluoropyrimidines?
Conclusion
Overexpression of uridine phosphorylase does not increase the sensitivity of MCF-7 breast cancer cells to fluoropyrimidines.
Takeaway
The study looked at whether a certain protein helps breast cancer cells respond better to a type of chemotherapy, but it turns out it doesn't.
Digital Object Identifier (DOI)
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