EFFECT OF D-ALLULOSE ON INSULIN RESISTANCE AND ENDURANCE ABILITY: IS D-ALLULOSE AN EXERCISE MIMETIC?
2024
Effect of D-Allulose on Insulin Resistance and Endurance Ability
publication
Author Information
Author(s): Koike Teruhiko, Gou Yang, Liu Bingyang, Natsume Yukie, Tsuzuki Takamasa, Shahriar Kamal, Banno Ryoichi
Primary Institution: Nagoya University
Hypothesis
Is D-allulose an exercise mimetic?
Conclusion
D-allulose administration improves insulin sensitivity and enhances endurance ability like exercise training.
Supporting Evidence
- D-allulose increases the glucose infusion rate in high-fat or high-sucrose diet-fed rat models.
- D-allulose administration leads to higher insulin-induced phosphorylation of AKT in skeletal muscle.
- D-allulose enhances insulin sensitivity and increases running distance in a healthy mice model.
- The improved exercise performance with D-allulose is associated with lower blood lactate levels.
Takeaway
D-allulose is a special sugar that can help your body use insulin better and make you run faster, just like exercising.
Methodology
The study used high-fat or high-sucrose diet-fed rat models and a healthy mice model to assess the effects of D-allulose on insulin sensitivity and exercise performance.
Digital Object Identifier (DOI)
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