TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions
2025
TCR3d 2.0: Expanding the T Cell Receptor Structure Database
publication
Evidence: high
Author Information
Author(s): Lin Valerie, Cheung Melyssa, Gowthaman Ragul, Eisenberg Maya, Baker Brian M, Pierce Brian G
Primary Institution: University of Maryland
Conclusion
The TCR3d database has significantly expanded its content and features, enhancing its utility for immunology and structural biology research.
Supporting Evidence
- The TCR3d database has grown by over 50% in available TCR–peptide–MHC complex structures since its original release.
- New tools for calculating TCR engagement angles and center of mass positions have been added to the TCR3d web interface.
- 253 affinity values for TCR–peptide–MHC complexes are now available, facilitating TCR design and affinity prediction methods.
Takeaway
TCR3d is like a big library that helps scientists understand how T cells recognize germs and can help design new medicines and vaccines.
Methodology
The database was updated with new tables for TCR mimic antibody complexes, TCR-CD3 complexes, and binding affinity data, along with tools for calculating docking geometries.
Digital Object Identifier (DOI)
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