Anastrozole and Tamoxifen in Breast Cancer
Author Information
Author(s): Dowsett M, Tobias J S, Howell A, Blackman G M, Welch H, King N, Ponzone R, Euler M von, Baum M
Primary Institution: Academic Department of Biochemistry, Royal Marsden Hospital, London, UK
Hypothesis
Does anastrozole affect the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer?
Conclusion
Anastrozole does not affect the pharmacokinetics of tamoxifen and effectively suppresses oestradiol levels when used together.
Supporting Evidence
- 34 post-menopausal women participated in the trial.
- Patients were randomized to receive either anastrozole or placebo.
- No significant difference in serum tamoxifen concentrations was observed.
- Oestradiol levels were significantly suppressed in the anastrozole group.
- The combination of tamoxifen and anastrozole was well tolerated.
Takeaway
This study looked at how two cancer drugs work together in women. It found that one drug doesn't change how the other works, and both can be taken safely together.
Methodology
Randomized, double-blind, parallel-group, multicentre trial with participants receiving either anastrozole or placebo.
Participant Demographics
Post-menopausal women with early breast cancer.
Statistical Information
P-Value
0.919
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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