AGE AND LOSARTAN EFFECTS ON MITOCHONDRIAL PROTEOME IN MICE
2024
Effects of Aging and Losartan on Mitochondrial Proteins in Mice
publication
Author Information
Author(s): Said Adam, Bene Michael, Abadir Michael, Kreimer Simion, Marx Ruth, Powell Laura, Walston Jeremy
Primary Institution: Emory College of Arts and Sciences
Hypothesis
This study investigated the effects of aging and Losartan on the mitochondrial proteome in mice.
Conclusion
Losartan may help counteract age-related declines in mitochondrial function.
Supporting Evidence
- Aged mice showed downregulation of certain proteins compared to young mice.
- Losartan treatment in aged mice upregulated some proteins related to energy production.
- At 33 months, no significant changes were observed in losartan-treated mice.
Takeaway
As mice get older, their cells' energy factories don't work as well, but a medicine called Losartan might help fix that.
Methodology
Mitochondrial samples from young and aged mice were analyzed using Cytoscape.
Limitations
The study suggests that advanced age may prevent the regulatory effects of Losartan.
Participant Demographics
Mice aged 3 months, 24 months, and 33 months were used in the study.
Digital Object Identifier (DOI)
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