Preventing Preterm Birth Mediated by Infection
Author Information
Author(s): James A. McGregor, Janice I. French
Primary Institution: University of Colorado Health Sciences Center
Hypothesis
Reproductive tract infections and subsequent inflammation cause significant numbers of women to suffer preterm labor, pPROM, and preterm birth.
Conclusion
Prompt diagnosis and systemic antibiotic treatment during pregnancy can prevent many preterm births caused by infections.
Supporting Evidence
- Treatment of bacterial vaginosis reduced idiopathic preterm birth by 70%.
- Routine screening and treatment of infections reduced preterm birth and PROM by approximately 50%.
- Significant reductions in low birth weight and preterm birth were observed with effective treatment of infections.
Takeaway
Infections in pregnant women can lead to early births, but treating these infections can help keep babies safe and healthy.
Methodology
The study involved a controlled, prospective evaluation of screening and treating prevalent infections to reduce preterm birth.
Limitations
The study did not account for costs incurred after neonatal discharge or increased liability costs due to adverse pregnancy outcomes.
Participant Demographics
Women considered to be at both 'high' or 'normal' risk for preterm birth.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI
Statistical Significance
p<0.05
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