Butyrate augments interferon-α-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells
1999
Butyrate and Interferon-α in Cancer Treatment
publication
Author Information
Author(s): Miyachi T, Adachi M, Hinoda Y, Imai K
Primary Institution: The First Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8543, Japan
Hypothesis
Does sodium butyrate enhance the effects of interferon-α on leukaemic cells?
Conclusion
Sodium butyrate enhances the S phase accumulation in leukaemic cells when combined with interferon-α.
Supporting Evidence
- Interferon-α induces a significant increase in the S phase population in K562 cells.
- Sodium butyrate enhances the effect of interferon-α on S phase accumulation.
- Persistent tyrosine phosphorylation of cdc2 is associated with S phase accumulation.
Takeaway
This study shows that a substance called butyrate can help a cancer treatment work better by making more cancer cells enter a specific phase of their growth cycle.
Digital Object Identifier (DOI)
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