Wound Healing Effects of Carapa guianensis Leaf Extract
Author Information
Author(s): B. Shivananda Nayak, Kanhai Joel, Milne David Malcolm, Pereira Lexley Pinto, Swanston William H.
Primary Institution: The University of the West Indies
Hypothesis
Does the ethanolic extract of Carapa guianensis leaf promote wound healing?
Conclusion
The leaf extract of Carapa guianensis facilitates wound healing in experimental animal models.
Supporting Evidence
- Extract-treated animals showed 100% reduction in wound area compared to 95% in controls.
- Skin breaking strength was significantly higher in extract-treated animals.
- Hydroxyproline content was significantly increased in extract-treated animals.
Takeaway
This study found that a plant called Carapa guianensis can help heal wounds faster in rats.
Methodology
The study used excision, incision, and dead space wound models in rats to evaluate the wound healing activity of the ethanolic extract.
Limitations
The extract did not demonstrate antibacterial activity, and further studies are needed to isolate active compounds.
Participant Demographics
Healthy inbred male Sprague Dawley rats weighing 180–200 g were used.
Statistical Information
P-Value
p<0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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