Outcome and complications in infants with respiratory failure: venovenous two-site versus double-lumen ECMO
2011

Comparing ECMO Techniques in Infants

Sample size: 270 publication Evidence: moderate

Author Information

Author(s): Hermon M, Mostafa G, Golej J, Burda G, Vargha R, Trittenwein G

Primary Institution: Medical University of Vienna, Austria

Hypothesis

Is there a difference in outcomes and complications between two-site venovenous ECMO and double-lumen ECMO in infants with respiratory failure?

Conclusion

Both ECMO techniques showed similar complication rates and survival outcomes, but the two-site method had a shorter duration.

Supporting Evidence

  • 87% of the children were treated with double-lumen ECMO.
  • APGAR scores were significantly lower in the two-site group.
  • ECMO duration was significantly shorter in the two-site group.
  • Survival rates were not significantly different between the two groups.

Takeaway

The study looked at two ways to help babies with breathing problems using a machine. Both ways worked about the same, but one way took less time.

Methodology

Data was collected from the ELSO registry for children treated with ECMO between 1999 and 2009, focusing on those who met specific inclusion criteria.

Potential Biases

Potential bias in data collection from a single registry.

Limitations

The study is limited to data from a registry and may not capture all variables affecting outcomes.

Participant Demographics

Children ≤7 kg BW, with a focus on those older than 32 days.

Statistical Information

P-Value

< 0.01

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.1186/cc9590

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