Predictive Metabolite Signatures for Tuberculosis Progression
Author Information
Author(s): E. A. Daniel, Shubham Upadhyay, Selvachithiram Murugesan, Pattabiraman Sathyamurthi, Bhanu Brindha, Sivaprakasam Amsaveni, Kulkarni Vandana, Karyakarte Rajesh, Gaikwad Sanjay, Paradkar Mandar, Yogendra Shivakumar Shri Vijay Bala, Vidya Mave, Amita Gupta, Keshava Prasad, Luke Elizabeth Hanna
Primary Institution: National Institute for Research in Tuberculosis, Indian Council of Medical Research (ICMR), Chennai, India
Hypothesis
Can metabolic profiles in QuantiFERON supernatants predict the risk of progression to active tuberculosis in household contacts?
Conclusion
The study identified specific metabolite signatures that could predict the risk of progression to active tuberculosis.
Supporting Evidence
- 21 significantly dysregulated metabolites were identified in TB antigen-stimulated supernatants of Progressors.
- The combination of Malic acid and N-Arachidonoylglycine had a maximum AUC of 0.99.
- 18 significantly dysregulated metabolites were identified in unstimulated QuantiFERON supernatants of Progressors.
- The combination of Orotic acid and specific phosphatidylcholines had a maximum AUC of 0.98.
- Most dysregulated metabolites belonged to fatty acid and lipid metabolism pathways.
Takeaway
Researchers found certain chemicals in the blood that can help tell if someone might get sick with tuberculosis later on.
Methodology
The study analyzed metabolic profiles in QuantiFERON supernatants from 14 healthy household contacts who progressed to TB and 14 who remained healthy over two years.
Limitations
The cohort size was small and metabolites identified are putative, requiring further validation.
Participant Demographics
Participants included healthy household contacts of TB patients, matched for age and gender.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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