Survival Outcomes in Sinonasal Mucosal Melanoma
Author Information
Author(s): Rojas-Lechuga María Jesús, Jubés Sara, Molina-García Manuel, da Silva-Júnior Rui Milton Patricio, Sampieri Claudio, Langdon Cristóbal, Gras-Cabrerizo Juan Ramón, Bernal-Sprekelsen Manuel, Puig Susana, Alobid Isam
Primary Institution: Hospital Clinic of Barcelona, Universitat de Barcelona
Hypothesis
This systematic review and meta-analysis aim to evaluate overall survival rates in patients with sinonasal mucosal melanoma.
Conclusion
The study confirms the aggressive nature of sinonasal mucosal melanoma with poor survival outcomes, highlighting the urgent need for improved treatment strategies.
Supporting Evidence
- The 5-year overall survival rate was found to be 34.8%.
- Survival rates varied by geographic region, with the highest in America at 40.5%.
- Most patients (83.3%) underwent surgery as the primary treatment.
- Adjuvant radiotherapy was received by 53.9% of patients.
- Only 6.2% of patients received immunotherapy.
Takeaway
Sinonasal mucosal melanoma is a rare and aggressive cancer that is hard to treat, and most patients do not survive long after diagnosis.
Methodology
A systematic search was conducted across PubMed and Web of Science, including studies with 5-year overall survival rates, and meta-analyses were performed using a random-effects model.
Potential Biases
Publication bias was identified, with some studies reporting worse prognosis compared to others.
Limitations
The quality of available evidence was mainly moderate to high case series and retrospective studies, with significant heterogeneity in reporting survival outcomes.
Participant Demographics
The cohort included 2383 patients, with 1192 (50%) females and a weighted mean age of 65.4 years.
Statistical Information
P-Value
0.001
Confidence Interval
[95% CI = 30.6–39.5]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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