Thiolated Chitosan Nanoparticles Improve Theophylline Delivery for Asthma Treatment
Author Information
Author(s): Lee Dong-Won, Shirley Shawna A, Lockey Richard F, Mohapatra Shyam S
Primary Institution: University of South Florida College of Medicine
Hypothesis
The absorption of theophylline through bronchial mucosa could be enhanced by administration with thiolated chitosan nanoparticles (TCNs).
Conclusion
Intranasal delivery of theophylline complexed with TCNs augmented the anti-inflammatory effects of the drug compared to theophylline administered alone in a mouse model of allergic asthma.
Supporting Evidence
- Theophylline alone exerts a moderate anti-inflammatory effect.
- The effects of theophylline were significantly enhanced when delivered by TCNs.
- TCNs showed a considerable reduction in pulmonary inflammation compared to other treatments.
- Delivery of theophylline by TCNs significantly enhanced apoptosis of inflammatory cells.
Takeaway
Researchers found that using special nanoparticles to deliver a common asthma medicine made it work better in mice with allergies.
Methodology
A mouse model of allergic asthma was used to test the effects of theophylline delivered intranasally with TCNs.
Participant Demographics
BALB/c mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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