Western Diet and Insulin Signaling: Lessons from Laron Syndrome
Author Information
Author(s): Bodo C. Melnik, John Swen Malte, Gerd Schmitz
Primary Institution: University of Osnabrück; University Clinic of Regensburg
Hypothesis
Over-stimulation of insulin/IGF-1 signaling by Western diet may promote diseases of civilization.
Conclusion
Laron syndrome, characterized by decreased insulin/IGF-1 signaling, is associated with a reduced prevalence of acne, type 2 diabetes, and cancer, while Western diet promotes chronic diseases.
Supporting Evidence
- Individuals with Laron syndrome do not develop type 2 diabetes and are almost free of cancer.
- None of 230 individuals with Laron syndrome developed cancer according to a worldwide survey.
- High intake of hyperglycemic carbohydrates and insulinotropic dairy over-stimulates insulin/IGF-1 signaling.
Takeaway
Eating too much sugar and dairy can make you sick, but some people with a rare condition don't get sick because they don't have as much insulin in their bodies.
Limitations
Laron syndrome subjects are not longer lived than normal subjects and may die of cardiovascular diseases if not treated.
Participant Demographics
99 Ecuadorian individuals with Laron syndrome due to growth hormone receptor deficiency.
Digital Object Identifier (DOI)
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