IL-27 Receptor Overexpression Protects Mice from Autoimmune Diseases
Author Information
Author(s): Sugiyama N, Nakashima H, Yoshimura T, Sadanaga A, Shimizu S, Masutani K, Igawa T, Akahoshi M, Miyake K, Takeda A, Yoshimura A, Hamano S, Yoshida H
Primary Institution: Kyushu University
Hypothesis
The study investigates the role of interleukin 27 receptor α (WSX-1) in the development of autoimmune disorders in MRL/lpr mice.
Conclusion
Overexpression of WSX-1 in MRL/lpr mice protects them from developing autoimmune diseases.
Supporting Evidence
- TgH mice exhibited a prolonged lifespan and no apparent development of autoimmune nephritis.
- Production of anti-dsDNA antibody and total IgG and IgG2a were significantly lower in TgH mice.
- CD4+ splenic lymphocytes in TgH mice were more subject to IL27-mediated suppression of cytokine production.
Takeaway
Scientists made special mice that have more of a protein called WSX-1, and these mice got sick less often from autoimmune diseases.
Methodology
Two strains of WSX-1 transgenic mice were generated in the MRL/lpr background, and their effects on survival and autoimmune symptoms were studied.
Participant Demographics
Female MRL/lpr mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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